Avoid or Use Alternate Drug.Д¬omment: Coadministration of anticholinergic drugs and glucagon increase the risk of gastrointestinal adverse reactions due to additive effects on inhibition of gastrointestinal motility. Glucagon increases toxicity of aclidinium by Other (see comment). Xeris Pharmaceuticals, Inc 3208 Red River Street, Suite 300 Austin, TX 78705.

Orphan designation for treatment of hyperinsulinemic hypoglycemia (HH) Sponsor

1 mg SC may repeat in 15 min if necessary.в‰Ґ45 kg: 1 mg SC may repeat in 15 min if necessary.Indicated for severe hypoglycemia in pediatric and adult patients with diabetes aged в‰Ґ2 years.Weight в‰Ґ20 kg or unknown weight and age в‰Ґ6 years: 1 mg SC/IM/IV may repeat in 15 min if necessary q20min PRN.Weight Weight в‰Ґ25 kg or unknown weight and age в‰Ґ6 years: 1 mg SC/IM/IV may repeat in 15 min if necessary.0.5mg/0.1mL (single-dose prefilled syringe or HypoPen autoinjector)ДЄdminister oral glucose/IV dextrose to replete glycogen stores GlucaGen.Load: 50-150 mcg/kg IVP over 1 minute, THENДЈ-5 mg/hr or 50-100 mcg/kg/hr IV titrate infusion to achieve adequate clinical responseДosage Forms & Strengths injection, powder (GlucaGen, generic) Indicated off-label for overdose of beta blockers or calcium channel blockers To inhibit motility of colon: 0.5-0.75 mg IV over 1 min or 1-2 mg IMД«olus doses >1 mg administered IV may cause nausea and vomiting and are not recommendedДЄfter completing the diagnostic procedure, give oral carbohydrates to patients who have been fasting, if compatible with the diagnostic procedure applied Beta-Blocker & Calcium Channel Blocker Toxicity (Off-label) To inhibit motility of stomach and small bowel: 0.2-0.5 mg IV over 1 min or 1 mg IM Indicated for use during radiologic examinations to temporarily inhibit movement of the gastrointestinal tract Repeat q15min once or twice give dextrose as soon as it is available and if no responseДЄdminister supplemental carbohydrate to replete glycogen stores Diagnostic Aid Indicated for severe hypoglycemic reactions in patients with diabetes treated with insulinДЎ mg (1 unit) IM/SC/IV if no IV for dextrose 1mg/0.2mL (single-dose prefilled syringe or HypoPen autoinjector).Dosage Forms & Strengths injection, powder for reconstitution (GlucaGen, generic)

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